Aiming at the problem of the dependence between software system modules, a hybrid defect prediction model based on network representation learning was constructed by analyzing the network structure of software system. Firstly, the software system was converted into a software network on a module-by-module basis. Then, network representation technique was used to perform the unsupervised learning on the system structural feature of each module in software network. Finally, the system structural features and the semantic features learned by the convolutional neural network were combined to construct a hybrid defect prediction model. The experimental results show that the hybrid defect prediction model has better defect prediction effects in three open source softwares, poi, lucene and synapse of Apache, and its F1 index is respectively 3.8%, 1.0%, 4.1% higher than that of the optimal model based on Convolutional Neural Network (CNN). Software network structure feature analysis provides an effective research thought for the construction of defect prediction model.